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Dextran-Chitosan Based In-Situ Gelling Hydrogels For Biomedical Applications A biodegradable hydrogel comprises a water-soluble dextran having aldehyde groups cross-linked with a water-soluble chitosan. Various chemical agents may be encapsulated in the hydrogel or bonded thereto for controlled release. The hydrogel may be applied as a coating to reduce the likelihood of bacterial attachment and biofilm growth; used in tissue... Published: 4/26/2021   |   Inventor(s): Xiaojun Yu, Chandra Valmikinathan Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)

Fabrication Of An Implantable Nerve Conduit Having A Polymer Fiber Spiral Guidance Channel Background:The spiral nerve guidance conduit is a biodegradable Polycaprolactone (PCL) spiral tube designed for bridging an injured peripheral nerve gap without tension and providing a large surface area for axon regrowth. In contract to our conduit, the traditional conduits support regeneration only along the tubular walls of the scaffolds which do... Published: 4/26/2021   |   Inventor(s): Xiaojun Yu, Wei Chang Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)

Fabrication of Injectable Nanofiber Reinforced Hydrogel Scaffold Invention Summary: The nanofiber-reinforced hydrogel scaffold is an innovative scaffold for the repair of focal cartilage defects in the articular region. It can be used as an augmentation of autologous chondrocyte implantation (ACI) by providing a vehicle for injection of the cell-laden scaffold into the defect. Compared with ACI, the nanofiber-reinforced... Published: 2/7/2014   |   Inventor(s): Hua Chen, Paul Lee, Xiaojun Yu Keywords(s):   Category(s): Medical

Fabrication of Injectable Nanofiber Reinforced Hydrogel Scaffold Invention Summary: The nanofiber-reinforced hydrogel scaffold is an innovative scaffold for the repair of focal cartilage defects in the articular region. It can be used as an augmentation of autologous chondrocyte implantation (ACI) by providing a vehicle for injection of the cell-laden scaffold into the defect. Compared with ACI, the nanofiber-reinforced... Published: 4/26/2021   |   Inventor(s): Xiaojun Yu, Paul Lee, Hua Chen Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)

Fabrication Of Biphasic Osteochondral Scaffold And Reconstruction Of Articular Cartilage Background:Articular cartilage covers the end of all diarthroidal joints, allowing the bones to slide against each other without actually coming into contact with each other. Due to the lack of vascularity above the subchondral region, healing of damaged cartilage is very rare. Thus, the body generally cannot heal the articular cartilage on its own... Published: 4/26/2021   |   Inventor(s): Xiaojun Yu, Paul Lee Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)

Microfluidic-Based Cell-Culturing Platform A microfluidic-based platform with cultured three-dimensional tissues simulates major human physiological systems for rapid evaluation of individual drugs prior to clinical testing or for personalized medical applications. The platform integrates the circulatory and lymphatic systems in a physiologically correct manner. The physiological systems may... Published: 4/26/2021   |   Inventor(s): Peter Tolias, Woo Young Lee, Arthur Ritter, Xiaojun Yu, Hongjun Wang, Henry Du, Chang-Hwan Choi, Wenting Zhang, Yexin Gu Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)