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Microfluidic 3D Osteocyte Network Reconstructured With Microbeads As Scaffold Background: Mature osteocytes embedded in the three-dimensional lacuna-canalicular network (3D-LCN) structure are known to sense local compressive strain and initiate strain-dependent new bone formation by osteoblasts, utilizing cytokines such as sclerostin and Dkk1 expressed by the osteocytes as major signaling molecules. Studying these osteocytes... Published: 4/26/2021   |   Inventor(s): Woo Young Lee, Yexin Gu, Wenting Zhang, Qiaoling Sun, Jenny Zilberberg Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)

Microfluidic-Based Cell-Culturing Platform A microfluidic-based platform with cultured three-dimensional tissues simulates major human physiological systems for rapid evaluation of individual drugs prior to clinical testing or for personalized medical applications. The platform integrates the circulatory and lymphatic systems in a physiologically correct manner. The physiological systems may... Published: 4/26/2021   |   Inventor(s): Peter Tolias, Woo Young Lee, Arthur Ritter, Xiaojun Yu, Hongjun Wang, Henry Du, Chang-Hwan Choi, Wenting Zhang, Yexin Gu Keywords(s):   Category(s): Bio Technology (Rx, dev's, sys)